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M Endres: reports grants from Bayer and fees paid to the Charit from Abbott, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, BMS, Daiichi Sankyo, GSK, Sanofi, Covidien, Novartis, Pfizer, all outside the submitted work

Treatment protocols generally recommend: Initial phase: Twice-weekly injections for optimal results Maintenance phase: Monthly injections for sustained benefits Individual adjustments based on patient response Is a MIC B12 shot better than a pill

Furthermore, H&E staining showed that compared to the aorta of normal aging mice, the aorta of mice treated with FOXO4-DRI was thinner, and the PWV value was lower in the ultrasound detection results, which means that the mice treated with FOXO4-DRI had better vascular elasticity and better vascular function than normal aging mice (Figures 1D,E)